Imaging Cell Interiors and Atoms

A long sought capability has now been mastered.  We can now image atoms and also image theinterior of a cell.  So many hard sciencequestions have been waiting for this ability. A lot of work will be in the form of simple confirmation of accepted unconfirmedmodels.  This is great news for science.

Medical science wasmoving quickly and will now hugely accelerate with this ability.  It will no longer be necessary to be terriblysubtle when you may look at what is actually happening.

The point is that wecan now image a hydrogen atom.  We willnow see how other atoms are constructed and be able to look for design variations.  This is all huge and as stated it has beenlong anticipated.

DECEMBER 01, 2010

1. Kurzwelai reports thata European consortium has developed the Megaframe Imager, anultrafast camera capable of recording images at one million frames per second.It allows for cellular and sub-cellular imaging, neural imaging, biosensing,DNA and protein microarray scanning, automotive collision studies, andhigh-sensitivity astronomical observations.

Fluorescence lifetime of dye molecules is a sensitive reporter on localmicroenvironment which is generally independent of fluorophores concentrationand can be used as a means of discrimination between molecules with spectrallyoverlapping emission. It is therefore a potentially powerful multiplexeddetection modality in biosensing but requires extremely low light leveloperation typical of biological analyte concentrations, long data acquisitionperiods and on-chip processing capability to realize these advantages. Wereport here fluorescence lifetime data obtained using a CMOS-SPAD imager inconjunction with DNA microarrays and TIRF excitation geometry. This enablesacquisition of single photon arrival time histograms for a 320 pixel FLIM mapwithin less than 26 seconds exposure time. From this, we resolve distinctlifetime signatures corresponding to dye-labelled HCV and quantum-dot-labelledHCMV nucleic acid targets at concentrations as low as 10 nM.

See it for yourself: a new breakthrough in imaging technology using acombination of light and sound will allow health care providers to seemicroscopic details inside the body

Access to this level of detail potentially eliminates the need for some invasivebiopsies, but it also has the potential to help health care providers makediagnoses earlier than ever before—even before symptoms arise. 

A research team led by YuichiIkuhara, a professor of material science at the University of Tokyohave succeeded in taking an image of a single hydrogen atom, the smallest andlightest of the chemical elements.

Although it had been thought acquiring direct images of a hydrogenatom, whose diameter is about one-ten-millionth of a millimeter, wasimpossible, the team managed the feat with a state-of-the-art "scanningtransmission electron microscope" while examining vanadium hydride, ahydrogen storage material.

The microscope scanned an electron beam onto a tiny spot, placed at atheoretically calculated location, on the specimen to enable a detector to catchand film the image of the hydrogen atom as well as the vanadium atom.

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