HIV Cure Indicated

This is aprotocol that appears to actually cure HIV. It depends of introducing the genes of a door who is naturally immune,but as this case shows, it eliminates the disease or we think so.  HIV hides and reemerges when opportunityarises.  Yet this is a pretty good start.

The currentprotocols call for driving the HIV out of the blood stream back into its hideyholes and largely keeping them there. Not perfect, but certainly good enough to allow the victim to die of oldage.

I presumethat in the test case they have suspended the cocktail and HIV has failed toreemerge.  That sure looks like a cureand they are justified saying so.  We mayhave this in some form of general usage pretty quick

It is worthrecalling that HIV victims are now surviving and all sure would love to seethis horror off.  This happens to be thefirst believable solution.

Patientreportedly cured of HIV infection after stem cell transplant
21:22 December 14, 2010
Scanning electron micrograph of HIV-1 budding (in green) from culturedlymphocyte

AnHIV-infected man who received stem cell treatment for leukemia from a donorwith natural resistance to HIV infection appears to have been cured of HIV,according to a report on the NAM aidsmap website. Thetreatment, which was carried out in 2007, opens the possibility of a cure forHIV infection through the use of genetically engineered stem cells.

Thedonor who provided the bone marrow for the transplant had a natural resistanceto HIV infection due to the absence of the CCR5 co-receptor from his cells. HIVmost commonly uses CCR5 as a “docking station” to enter its target CD4 cellsand carriers of a genetic mutation of a portion of the CCR5 gene calledCCR5-delta 32 homozygosity have a reduced risk of becoming infected with HIV.

For aperiod of 38 months after the stem cell transplant the patient continued toreceive immunosuppressive treatment to prevent rejection of the stem cells.During this time the donor CD4 cells repopulated the mucosal immune system ofthe patient’s gut, accompanied by the complete disappearance of host CD4 cells.After two years the patient had the CD4 count of a healthy adult of the sameage but no detectable HIV infection.

The casewas first reported at the 2008 Conference on Retroviruses and OpportunisticInfections in Boston.Berlin doctors also published a detailed case history in the New England Journal of Medicine inFebruary 2009 and have now published a follow-up report in the journal Blood saying, “It is reasonableto conclude that cure of HIV infection has been achieved in this patient.”

Thesuccess of the treatment could pave the way for the development of a cure forHIV infection through the use of genetically engineered stem cells. Due to thesuccess of the treatment, scientists have been trying to coordinate efforts toidentify CCR5-delta 32 homozygosity donors to expand the supply of stem cellscarrying the genetic mutation, while several U.S. research groups have alsoreceived funding to investigate techniques for engineering and introducingthese types of stem cells.

The roadto a cure hasn’t been easy for the patient, Timothy Ray Brown, a U.S. citizen who lives in Berlin. While dealing with the lengthy andgrueling treatment for leukemia he suffered two relapses and underwent two stemtransplants. He them developed a serious neurological disorder that led to about of temporary blindness and memory problems. He is still undergoingphysiotherapy and speech therapy but now appears to be on the road to recovery.

However,in an interview with German news magazine Stern this week when asked if it would have been better tolive with HIV than to have beaten it in this way he said, “Perhaps. Perhaps itwould have been better, but I don’t ask those sorts of questions anymore.”

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