If the biochemistry of weightloss and gain were properly understood, then a solution would have long sincebeen indicated. Everyone knowsdifferent.
The take home is that an extractof African bush mango or Irvingia gabonensis called IGOB131is clearlyassociated with rapid weight reduction and plausibly with a resetting of the metabolicpathways to sustain that weight loss. Weare indicating two to three pounds each week been lost in the early fieldtrials.
More convincing is the absolutelack of obesity in the subject native populations using this product.
Of course the commercial marketersare jumping on this and are providing a usable product.
The extensive native usage is apretty good field test and suggests that it is safe to use. It is way to early to deliver definitivescience here but again use at ones own risk.
My point is that there is manyfailed weight loss protocols out there and most of the successful ones areexcessively demanding for easy sustainability. My on and off fasting protocol is the easiest that I am aware of and itis highly effective. Yet the actual monthlyloss is a sedate two and a half pounds per month. The body actually adjusts very slowly.
This small addition to one’s dietgenerates a weight loss that is around four times faster suggesting that theliterature is correct to suggest major changes in the metabolism.
This is extraordinary good newsparticularly for those suffering from outright obesity.
African Mango Irvingia gabonensis and Weight Loss, Review of
1 Oben JE, et al. “Irvingia gabonensis significantly reduces body weight andimproves metabolic parameters in overweight humans.” Lipids in Health andDisease. 2009, 8:7.
2 Reuters. “Exotic Fruit Extract May Shed Pounds, Lower Cholesterol.” March 24,2009. FOXNews.com.
3 Maeda H, et al. “Fucoxanthin shows antiobesity effect through UCP1 expressionin white adipose tissues.” Biochem Biophys Res Commun. 2005 Jul 1;332(2):392-7.
4 Sugawara T, et al. “Antiangiogenic activity of fucoxanthin.” J Agric FoodChem. 2006 Dec 27;54(26):9805-10.
5 Ramazanov, Z. “Effect of fucoxanthin on energy expenditure in obese women: adouble-blind, randomized and placebo-controlled trial.” Submitted for publication2008.
* These statements have not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure, or prevent any disease.
Alan Sears, M.D., is a practicing physician with extensive experience in thefields of complementary and natural healthcare. The recommendation andmaterials on this site represent his opinion based on his years of practicingmedicine. The information and material provided on this site are foreducational purposes only and any recommendations are not intended to replacethe advice of your physician. You are encouraged to seek advice from acompetent medical professional regarding the applicability of anyrecommendations with regard to your symptoms or condition. It is important thatyou do not reduce, change or discontinue any medication or treatment withoutconsulting your physician first. The personal stories shared on this websiteare personal to the users and will not be typical of the results you will haveif you follow the advice provided on this website.
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by JOE CANNON on OCTOBER 26, 2010
I’ve been getting a lot of questions about African Mango, also called Irvingiagabonensis and whether this fruit can help people lose weight. Africanmango is similar to the mango’s you’ve probably eaten at some point. So, tohelp you, I wanted to review it and give people a better idea of what it is,what the research says and whether it might help weight loss. On the web, youmay also see African Mango called Bush Mango or WildMango. All names refer to its scientific name, Irvingia gabonensis. Theextract of African mango that has been used in weight loss research is calledIGOB131.
This name is sometimes shortened to simply OB131. Keep this in mind asyou read this review.
Irvingia gabonensis / African mango research
There is indeed research on Irvingia gabonensis. More precisely thereis research on an extract from the seeds of the African mango tree. The extractis dubbed IGOB131. I am telling you this because if you try Irvingiagabonensis weight loss supplements, this is the ingredient that the researchwas conducted on. Other African mango extracts may not have the same effect.
In one 4 long week study, published in 2005 in the JournalLipids in Health and Disease, 40 overweight people were given either 3.15grams of Irvingia gabonensis or a comparable amount of oat bran 30minutes before meals, in conjunction with a low fat diet. People ate about 1800calories a day. At the end of this 4 week study, those receiving Irvingiagabonensis lost about 5.6% of body weight vs. those in the placebo groupwho lost about 1% of body weight. Body fat did not change significantlyin either group.
Body fat was measured using bioelectric impedance analysis, a methodcommonly used in health clubs. This method, while quick and easy to administer,is less accurate than other means like hydrostatic weighing, Bod Pod etc.
Systolic blood pressure (the top blood pressure number) was reducedabout 4 points after the 4 week study. This drop in systolic bloodpressure could be simply due to the weight loss experienced as opposed to adirect effect of Irvingia gabonensis itself.
In a 10 week study, published in 2009 in the journal, Lipids in Health and Disease, 102 healthy overweightmen and women were followed for 10 weeks. People were split into either aplacebo group or a group that received 350 mg of Irvingia gabonensis. TheIrvingia gabonensis was supplied by Gateway Health Alliances Inc(
). Fairfield CA
In those receiving the Irvingia gabonensis extract, body weight, bodyfat and waist circumference had decreased more than in the placebo group. Thosegetting IGOB131 lost 28 pounds vs. about 1 pound for those getting the placebo.Body fat was determined using bioelectric impedance analysis.
LDL cholesterol (bad cholesterol), total cholesterol, blood glucose,and C reactive protein were also lower in those who received the Irvingiagabonensis extract.
The weight loss observed in the African Mango group could account forthe the decreases in cholesterol, blood glucose and C reactive protein. Thesethings do change when people lose weight. The soluble fiber in the extract mayalso had an effect on cholesterol levels.
Another study published in 2009 in Lipids in Health and Disease by the same researchersexposed mouse cells to IGOB131 and noted that the compound increased fat cellproduction of adiponectin. Research finds that adiponectin has antiinflammatory properties and that high levels of adiponectin appear tobe correlated with a lower a lower risk of heart disease. This same study notedthat IGOB131 inhibited fat cell development as well.
African mango and leptin
The 10 week long study published in 2009 also noted that the IGOB131extract reduced levels of leptin. Leptin is a hormone made inside fat cellswhich plays a role in appetite. Basically this is what happens:
When leptin levels rise, we stop eating
When leptin levels fall, we get hungry
That’s the easy answer. The amount of leptin we have is dependent onhow much body fat we have. So, the more body fat, the higher the leptin levels.One problem however is that many overweight people (who make a lot of leptin)are insensitive to the leptin and it doesn’t work to stop them from eating. Inother words they areleptin resistant.
Because Irvingia gabonensis lowered leptin levels, some take this to meanthat it helps weight loss. But, remember that as leptin levels decrease, we gethungry. I’m saying this because the decrease in leptin that was observed in the10 week long 2009 study appear to be a result of IGOB131 reducing fat cellgrowth and differentiation. In other words, as fat cell growth slows, leptinlevels might fall also.
If the African mango extract does reduce leptin levels, would acontinued drop in leptin cause a rebound hunger in people, causing them to eatmore? I don’t know? The longest study so far has only lasted 10 weeks. Thebottom line to all this talk about leptin is that leptin is not the only playerin the game when it comes to obesity. If Irvingia gabonensis has any realeffect on combating weight loss, its effects on leptin are probably not theanswer.
Will African mango work?
Everybody is different but the preliminary research is intriguing. IfIrvingia gabonensis extracts are going to work, it will probably take at least4 weeks before people notice a decrease in weight. Taking the Irvingiagabonensis extract 30 minutes before meals with water (as was done in the humantrials) may increase the chances of success.
Things to think about
It is important for people to remember that all of the positiveresearch on African mango (Irvingia gabonensis) has used a specific extractcalled IGOB131. Consumers should look for the amount of IGOB131 on supplementlabels. Supplements containing whole African mango or other extractsof African mango may not have the same effects.
Even though the research to date should be considered preliminary, sofar there are 2 human trials and both of the studies indicate that some weightloss effect is occurring.
According to the research so far, best results appear to have occurredwhen people take between 350 mg to 3 grams of irvingia gabonensis perday. This is a large range so people may want to start with 150-350 mgfirst and see how they feel before they increase the dosage if needed.Obtaining good results is probably better if African mango is combined with alow fat / low calorie diet.
Don’t be swayed by the amount of Irvingia gabonensis a supplementcontains. Look instead for how much of theIGOB131 extract the product has.This is what the research uses.
No study to date has investigated if exercise speeds weight loss withAfrican mango. In theory it should. Regardless, research does show thatexercise, in conjunction with dieting, increases the percentages ofweight that’s lost as fat. Remember we don’t just want weight loss.We want fat loss. Dieting alone can lead to significant muscle loss, whichlowers metabolism, making it harder to lose weight.
At least one of the studies has been sponsored by a supplement company.Some may look as this as a conflict of interest. However since pharmaceuticalcompanies perform much of their own research, I appreciate it when a supplementcompany takes the time to publish research on their products. As long as theresearch studies are well designed and the company has not influenced theoutcomes, I have no problem with this.
Weight loss could account for the observed changes in total cholesteroland LDL and CRP. Some have attributed the effects of African Mango to itssoluble fiber content but I think this may be premature. In other words, I’dlike to see more studies done.
Only one study has noted that Irvingia gabonensis lowered leptinlevels. Most weight management researchers view leptin as one of many factorsinfluencing weight loss. Leptin alone, is not the answer.
So far, side effects from Irvingia gabonensis appear mild withsleeplessness, headache and gas reported. How Irvingia gabonensis interactswith medications you might be taking is unknown.