Baldness Cured

This is no minor improvement atall.  It looks like the whole enchilada.  It easily explains baldness in its variousforms and directly cures the problem.  Sofar it looks good for four months after treatment.  I suspect it is good for much longer,depending on the build up of CRF.  For lowlevel problems such as shock related hair loss the fix is possibly permanent.

Yet even for men facing earlyonset baldness who are clearly in most need, this result supports a quarterly treatmentat worst.

For all facing age related hairloss, we are looking at what may well be a complete fix for most.

Follicle restoration may well beanother matter for most though.

From the images we are seeing afull and complete restoration, rather than a small improvement which has beenthe best anyone has ever achieved.

Perhaps we will all be sporting afull thick head of hair rather soon, and I do mean everyone. 

Nothing is clear yet regardingthe effect on hair color.  One presumesthat white hair is a natural outcome that is independent of this particularfactor but that is unclear also.

Researchers stumble on potential new treatment for hair loss

21:29 February 17, 2011

While conducting research into brain-gut interactions, a team led byresearchers from UCLA andthe Veterans Administration may have inadvertently stumbled across a newtreatment for hair loss. During an investigation into the affect of stress ongastrointestinal function, the researchers believe they may have found achemical compound that induces hair growth by blocking a stress-related hormoneassociated with hair loss.

It’s long been recognized that stress plays a role in hair loss and,although there have been numerous hair-restoration remedies emerge over theyears, even legitimate medications such as minoxidil have only shown limitedeffectiveness. The UCLA-led team says their findings show that the chemicalcompound they have uncovered could provide long-term hair regrowth from ashort-duration treatment.

Instead of looking for mice burdened with debt or in the process ofmoving house, for their research the researchers had been using mice that weregenetically altered to overproduce a stress hormone calledcorticotrophin-releasing factor, or CRF. As these mice age, they lose hair andeventually become bald on their backs, making them visually distinct from theirunaltered counterparts.

The UCLA and VA researchers then injected a peptide called astressin-B,which has the ability to block the action of CRF, into the bald mice to observehow its CRF-blocking ability affected gastrointestinal tract function. When theinitial single injection had no effect the investigators continued theinjections over five days to give the peptide a better chance of blocking theCRF receptors. They measured the effects of this regimen on the stress-inducedresponse in the colons of the mice and placed the mice back in the cages withtheir hairy counterparts.

Three months later the researchers returned to the mice to conductfurther gastrointestinal studies and found they couldn’t distinguish them fromtheir unaltered brethren as their previously bald backs were now covered inhair.

"When we analyzed the identification number of the mice that hadgrown hair we found that, indeed, the astressin-B peptide was responsible forthe remarkable hair growth in the bald mice," said Million Mulugeta, anadjunct professor of medicine in the division of digestive diseases at theDavid Geffen School of Medicine at UCLA and a corresponding author of theresearch. "Subsequent studies confirmed this unequivocally,” he added.

Particularly noteworthy was the fact that just one injection a day forfive consecutive days was enough to maintain the effects for up to four months.

"This is a comparatively long time, considering that mice's lifespan is less than two years," Mulugeta said.

Whether the same effect happens in humans remains to be seen, but theresearchers say the fact that the bald mice also showed mild hair growth whentreated with minoxidil alone, as is the case in humans, suggests thatastressin-B could also produce hair regrowthin humans. In fact, it is known that the stress-hormone CRF, its receptors andother peptides that modulate these receptors are found in human skin.

UCLA and the Salk Institute haveapplied for a patent on the use of the astressin-B peptide for hair growth.

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